According to Robert Gadimian of Rophe Pharma, the majority of individuals that acquire skin cancers are typically exposed to conventional treatment using the cut (surgery), poison (chemotherapy) and burn (radiation) approach. Gadimian believes a safe, effective and relatively inexpensive natural alternative to the standard model is badly needed.
LOS ANGELES, December 28, 2017 (Newswire.com) - Topical Treatment derived from BEC5 found in Eggplant.
Skin cancer incidence is increasing at alarming rates and is among the highest of the cancer types. The incidences of nonmelanoma skin cancers such as basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) have increased more than 300% since 1992. For malignant melanoma, increased rates of over 500% have been reported from 1975 to 2008. The development of new treatments, unfortunately, has not caught up with the increased incidences of this disease.
A variety of procedures are available with differing success outcomes. The limitations and costs of current treatments for skin cancers pose many shortfalls. In fact, many patients afflicted with these diseases do not properly seek treatment, resulting in increased morbidity and mortality. According to Robert Gadimian of Rophe Pharma, the majority of individuals that acquire skin cancers are typically exposed to conventional treatment using the cut (surgery), poison (chemotherapy) and burn (radiation) approach. Gadimian believes a safe, effective and relatively inexpensive natural alternative to the standard model is badly needed.
Basal cell carcinoma is a slow-growing, locally invasive malignant skin tumor which mainly affects Caucasians. Dermatologists, plastic surgeons and radiotherapists jointly manage this disease, which usually involves surgery and surgical intervention and thus, is not without risks. Excision of basal cell carcinoma from the facial area often involves reconstructive surgery, which can be time consuming and expensive. Hence an alternative, safe and efficacious method of treatment of basal cell carcinoma that does not require an attending physician or hospital visit is not only preferred but is also a cheaper and, more importantly, much safer alternative.
Gadimian says the good news is that recently a novel topical natural treatment has surfaced and it has many advantages over the currently used skin cancer therapies. The treatment is a topical cream that contains an eggplant extract called BEC5.
Novel Treatment from the Humble Eggplant
BEC5 consists of the antineoplastic compounds solasodine, rhamnosyl glycosides, solamargine and solasonine, which are derived from the eggplant and are very effective for treating nonmelanoma skin cancers. Advantages of treatment of these lesions with BEC5 compared with well-established surgical interventions and other therapies have been reported in the scientific literature [Reference 1-10].
The treatment time period with topical BEC5 to completely eliminate skin cancers varies from days to months depending on size and type of the skin tumors. Large nonmelanoma skin cancers can successfully be treated with BEC5 but it may take several months of treatment to eliminate these large tumors [Reference 1-10].
Unlike established antimitotic drugs, BEC is not antimitotic in its actions. BEC induces apoptosis (planned self-destruction of cells) in cancer cells by up-regulating the expressions of external death receptors. BEC also triggers extrinsic and intrinsic apoptotic pathways in cancer cells [Reference 1-10].
Solamargine, the main component of BEC, also kills cancer cells by oncosis. After interaction of solamargine with cancer cells, marked changes in cell shape and volume occur. The cells get blebs (bulges or protrusions) on the membrane, the mitochondria swell, the contents of the nuclei clump and the cells die. It has been proposed that apoptosis and oncosis share certain mechanisms and alterations within the cell before they die by bursting. At low concentrations, solamargine kills cancer cells by apoptosis and at higher doses, solamargine kills cancer cells by oncosis. Both types of cell death are induced by intermediate concentrations of solamargine. Thus, the beauty of BEC is that it penetrates and kills cancer cells but does not penetrate normal cells. Normal cells are untouched and unhurt while the cancer cells die.
It has recently been shown that, in addition to causing apoptosis in cancer cells, intralesion administration of BEC also stimulates lasting immunity against cancer.
BEC has also shown in a clinical study done with 78 patients to cure actinic keratosis that can advance to squamous cell carcinoma, which in turn is associated with a risk of metastasis. In this study, 92% of the patients had complete clearance after treatment and had 82% clearance after one year.
In conclusion, for individuals with skin cancer, BEC could be a very viable alternative to current cancer treatments, especially considering its safety and efficacy.
So … the next time you grill up a slice of eggplant you might want to pause and consider the cancer-killing properties of this common food. (Fact: Eggplant is actually a fruit, not, as is commonly believed, a vegetable.)
- T. R. Chase, “Curaderm BEC5 for Skin Cancers, Is It? An Overview,” Journal Cancer Therapy, Vol. 2, No. 5, 2011, pp. 728-745.
- B. E. Cham, “Eggplant Wins War against Skin Cancer. Conquest on the Horizon for Internal Cancers?” in Preparation.
- B. E. Cham, “The Eggplant Cancer Cure. A Treatment for Skin Cancer and New Hope for Other Cancers from Nature’s Pharmacy,” Smart Publications, Petaluma, 2007, p. 122.
- B. E. Cham, “Solasodine Rhamnosyl Glycosides Specifically Bind Cancer Cell Receptors and Induce Apoptosis and Necrosis. Treatment for Skin Cancer and Hope for Internal Cancers,” Research Journal Biological Sciences, Vol. 2, No. 7, 2007, pp. 503-514.
- B. E. Cham, “Solasodine Rhamnosyl Glycosides in a Cream Formulation Is Effective for Treating Large and Troublesome Skin Cancers,” Research Journal Biological Sciences, Vol. 2, No. 7, 2007, pp. 749-761.
- B. E. Cham and T. R. Chase, “Solasodine Rhamnosyl Glycosides Cause Apoptosis in Cancer Cells, Do They also Prime the Immune System Resulting in Long Term Protection against Cancer?” Planta Medica, Vol. 78, 2012, pp. 349-353. doi:10.1055/s-0031-1298149 [Citation Time(s):2]
- B. E. Cham, “Monograph on the Compound BEC,” Drugs of the Future, Vol. 13, 1988, pp. 714-716.
- B. E. Cham, “Solasodine Glycosides as Anti-Cancer Agents: Pre-Clinical and Clinical Studies,” Asia Pacific Journal Pharmacology, Vol. 9, No. 2, 1994, pp. 113-118.
- B. E. Cham and B. Daunter, “Topical Treatment of Pre-Malignant and Malignant Skin Cancers with Curaderm,” Drugs of Today, Vol. 26, No. 3, 1990, pp. 55-58.
- B. E. Cham, B. Daunter and R. Evans, “Topical Treatment of Malignant and Premalignant Skin Cancers by Very Low Concentrations of a Standard Mixture of Solasodine Glycosides,” Cancer Letters, Vol. 59, No. 3, 1991, pp. 183-192.
- B. E. Cham and M. M. Meares, “Glycoalkaloids from Solanum sodomaeum L. Are Effective in the Treatment of Skin Cancers in Man,” Cancer Letters, Vol. 36, No. 2, 1987, pp. 111-118.
- S. Punjabi, I. Cook, P. Kersey, R. Marks, A. Finlay and G. Sharpe, “A Double Blind, Multi-Centre Parallel Group Study of BEC-5 Cream in Basal Cell Carcinoma,” European Academy Dermatology Venereology, Vol. 14, 2000, pp. 47-60.
- S. Punjabi, L. J. Cook, P. Kersey, R. Marks and R. Cerio, “Solasodine Glycoalkaloids: A Novel Topical Therapy for Basal Cell Carcinoma. A Double-Blind, Randomized, Placebo-Controlled, Parallel Group, Multicentre Study,” International Journal Dermatology, Vol. 47, No. 1, 2008, pp. 78-82.
Source: Robert Gadimian, Owner of Rophe Pharma